I think a party that wins the youth who soured on Big Government will be the engine for the next reshaping of American Politics. My take is that a third party is most likely to catch the current because neither Democrats or Republicans have an inspiring policy engine. Add a little populism to that. Hello Sarah Palin and friends.
UPDATE: Professor Jost, an Obamacare supporter, is quoted at the Huffington Post : "If the whole thing collapses, it'll be another generation before we get this problem fixed."