Cancer spreads with sharp elbows. Switching off the JAK protein may stop metastasis.

Some cancer cells elbow their way out of a tumor and into new sites with contractions triggered by the JAK protein.  90% of cancer deaths occur after metastasis, when cancer spreads to other parts of the body. Finding an OFF switch for the protein may keep cancer parked in one spot and save many lives.
Protein JAK Makes Cancer Cells Contract, So They Can Squeeze Out ...

This image of an active region of JAK
 wows me