Wednesday, 13 May 2020

Coronavirus Vaccine: Get some context

Daily headlines tout a new vaccine breakthrough.  If the story is simple, it's not useful.

Excerpted:
There are at least 8 promising vaccines in active global development, not just one.
Vaccines can last a lifetime (smallpox) or five years (shingles, tetanus).  No one knows how this will work for the Wuhan flu virus.  To date, no one anywhere has developed a vaccine against a coronavirus  (SARS is a coronavirus).
The Wuhan virus (before it enters your cells ) has three sites than can be targeted with a neutralizing antibody:  Each works differently.  There's the capsid N protein and on the S spike are sites S1 and S2.
Amplified:  A vaccine has to deal with a moving target.  One ampoule is unlikely to fix you forever.  All viruses are mutating all the time, and since their generation is measured in hours rather than decades, things move along briskly and usually without much consequence.  There are already dozens of subspecies around, just like there are Scots and Englishmen and within England there are Lancashiremen and Cockneys, but still pretty much all homo sapiens.   Don't freak out about "THE VIRUS IS MUTATING OMG" stories.


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