Tuesday, 19 May 2020

Mouse Brain Has An Off Switch For Pain. Please Be True For People Too.

There is new hope for fixing chronic pain.  The mouse brain amygdala has a region that can profoundly damp the sensation of pain.  The amygdala harbors protocols for fight-or-flight and general anxiety.

Sufferers of chronic pain don't need to be reminded every minute of every day that something is wrong.  They got the message.  They deserve a break.

Previous searches were for brain locations that turn ON pain, hoping to disable the ON switch. This report describes a region that actively turns OFF pain.  A stimulus instead of an antagonist may do the trick.

The source paper in Nature is linked here.  The research was into why general anesthesia works.  They found a population of cells in the amygdala that were stimulated by it.


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